Findings & Breakthroughs
Trials Breakthrough Multi-arm platform trial coming
One trial design will test several drugs. Arms start at about 12 patients and grow to about 30 with a signal. Pooled data from 12 past trials serves as the comparison group, so fewer patients are randomized. It opens first at about 4-6 US sites.
Gregory Cote · Massachusetts General Hospital
· Clinical Trials & the New Platform Trial
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Trials Survey: avoid placebo, use crossover
Only 12% would join a placebo-controlled trial. That rises to 45% with crossover and 59% with an active comparison drug. 84% would join a trial that could shrink the tumor.
Pam Loeb · Edge Research
· Clinical Trial Participation Survey Results
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Trials Trial Travel Assistance funds available now
The program is well funded. Only about a quarter of patients knew about it, and 80% said it would make them more likely to join a trial.
Josh Sommer · Chordoma Foundation
· Table Discussions: Research & Trials
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Trials Regulators (FDA & EMA) at the table
Representatives attended and were described as open to a workable approval path. No chordoma drug has ever been approved, so there's no precedent to follow.
Josh Sommer · Chordoma Foundation
· Clinical Trial Participation Survey Results
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